所有作者：李茁 杨静 刘进 龚春雨 甘婧 张娴 罗文君 李国华
作者单位：四川大学药理教研室
论文摘要：Background： Studies have shown that the local use of volatile anesthetics can produce some local anesthetic effects。 The present study was designed to evaluate characteristics of nerve conduction block of emulsified isoflurane (EI)， and compare its nerve blockade with １％ lidocaine， by measuring compound nerve action potential (CNAP) parameters in isolated toad sciatic nerve。 Methods： One hundred isolated toad sciatic nerves were selected and randomly assigned to １０ groups of １０ each， receiving administration of ２-８％ EI (v/v) (EI８ group， etc)， １％ lidocaine (Lido group)， ３０％ Intralipid?(Lipid group) and Ringer?solution (RS group) for １０min， respectively。 Then all nerves were washed and soaked by RS for １０min and ３０min。 The nerve conduction block effect was represented by CNAP parameters which were recorded by extracellular recording technique per min。 Results： The results showed that the negative amplitudes of CNAP were decreased by EI as well as Lidocaine (P < ０。０５)， and the conduction velocities of CNAP were also decreased in some time points (D７-W３) (P < ０。０５)。 After RS washing， the two parameters recovered gradually。 The changes in the two parameters induced by EI had slower onset rates and faster recoveries than those produced by lidocaine (７ min vs。 １ min， ９ min vs。 ３０ min)。 The nerve blockade induced by EI was dose-dependent (P < ０。０５)， and the half maximal inhibition concentration of EI was ５。４６ ％。 Conclusions： EI produced completely reversible and dose-dependent nerve conduction inhibition， which had slower onset and faster recovery compared to those produced by lidocaine。
关键词： Emulsified Isoflurane Compound nerve action potential Local anesthetics Isolated toad sciatic nerve
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