所有作者：郭维生 罗辽复
作者单位：内蒙古大学理论生物物理研究室
论文摘要：Based on a simplified model of mechanochemical actin–activated myosin ATPase cycle the muscle state equation and muscle kinetic equation are deduced from the biochemical thermodynamic principles。 A set of chemical kinetic equations describing the cycle is established。 From the non-equilibrium steady state solution of the set of equations， the experimental data on the fraction of myosin heads in any biochemical state independent of the concentration of inorganic phosphate， [Pi]， and the data on the active， isometric muscle force varying logarithmically with [Pi] are explained。 Therefore， how force as a state variable coupled to chemical reaction in muscle system is clarified and the muscle state equation is set up。 Based on the muscle state equation， by using the interpolation formula which models the force versus extension of the parallel elastic component in muscle and taking the viscous frictional force into account， a kinetic equation for sarcomeres is given and through the solution of the equation， both contraction and spontaneous oscillation of sarcomeres are explained automatically。 The computational results agree well with experimental data。 In the last section of the paper the implications relating to the power stroke in the actin-myosin system are explored briefly in terms of the proposed simplified model on cross-bridge cycle。
关键词： myosin ATPase cycle chemical kinetic equations sarcomeres contraction and oscillation kinetic equat
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